Abstract
Currently available anti-HIV-1 drugs suppress viral replication and maintain viral levels below the detection threshold of most assays but do not eliminate cellular reservoirs. As a result, very low levels of circulating virus can be detected in most people despite long–term treatment with potent anti–HIV drug combinations. Not surprisingly, viral levels rebound with discontinuation of treatment. New evidence indicates that there is a viral reservoir in bone marrow progenitor cells.
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Acknowledgements
Funding for this work was received from the National Institutes of Health and the Burroughs Wellcome Fund. LM is a recipient of an NSF pre-doctoral fellowship and a Bernard Maas Fellowship.
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Onafuwa-Nuga, A., McNamara, L. & Collins, K. Towards a cure for HIV: the identification and characterization of HIV reservoirs in optimally treated people. Cell Res 20, 1185–1187 (2010). https://doi.org/10.1038/cr.2010.140
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DOI: https://doi.org/10.1038/cr.2010.140
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