Figure 1
From: Hepatitis C virus' Achilles' heel – dependence on liver-specific microRNA miR-122
Effects of microRNA miR-122 on cholesterol biosynthesis and Hepatitis C virus. Stimulation of the cholesterol biosynthesis pathway by miR-122 is shown on the left. The Lovastatin target and the rate limiting enzyme of the pathway, HMGCR, is highlighted. Interaction of miR-122 with HCV RNA via two complementary binding sites in the5′ nontranslated region of the viral genome is shown on the right. The novel miR-122 inhibitor, an antisense locked nucleic acid (LNA) oligonucleotide, termed SPC3649, is shown. HMGCR, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase. PP, pyrophosphate.
