Figure 1
The scheme illustrates the MDF1-ADF1 sense-antisense regulatory module. Loss of transcriptional repression by Adf1p leads to ectopic expression of MDF1 in haploid α cells. By forming a heterodimer with α2p, Mdf1p leads to repression of haploid-specific genes (including MATα1) in α cells, thus blocking the mating pathway and favoring vegetative growth over mating. It is unknown whether Mdf1p functions in diploids, in which case it is likely that Mdf1p competes with a1p (dotted circles) for α2p binding, possibly regulating expression of additional genes.
