Figure 1 | Cell Research

Figure 1

From: Chronic lymphocytic leukemia: A tale of one or two signals?

Figure 1

BCR signals generated in CLL B cells. (A) Conventional antigen-dependent BCR signal generated by crosslinking of neighboring BCRs by an external self- or foreign antigen or an antigen surrogate such as anti-IgM antibodies. (B) Cell-autonomous BCR signal generated by an inter-molecular interaction between the HCDR3 of one smIg and the FR2 of a neighboring smIg. (C) Cell-autonomous BCR signal generated by an intra-molecular interaction between the HCDR3 and FR2 of the same smIg.

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