Figure 6
From: A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons
Introduction of Trp53 mutations in Nbs1-deficient brain largely rescues microcephaly. (A) Western blot analysis of p53 protein in Nbs1-deficient and -proficient brains at P7. (B) Brain weight from at least 10 mice of each genotype. *P < 0.01 (t test). (C) Histological analysis of Trp53 mutant Nbs1-deficient cerebrum. Cx, cerebral cortex; CC, corpus callosum; DG, dentate gyrus; CA1/CA3, field CA1/CA3 of hippocampus. Original magnification ×4. (D) Expression level of Hzf protein in P7 Trp53 mutant Nbs1-deficient cortex and cerebella.
