Figure 1 | Cell Research

Figure 1

From: InsP3R-Ca2+ signaling takes center stage in the hormonal regulation of hepatic gluconeogenesis

Figure 1

Opposing signaling pathways triggered by glucagon and insulin converge on InsP3Rs and thereby regulate CRTC2-dependent gluconeogenesis in a Ca2+- and calcineurin-dependent manner. During fasting, glucagon activates InsP3Rs via PKA-dependent phosphorylation, leading to the activation of calcineurin and subsequent dephosphorylation of CRTC2, thereby resulting in the induction of gluconeogenic genes. Under feeding conditions, insulin inactivates InsP3Rs via Akt-dependent phosphorylation, leading to the inhibition of calcineurin-dependent dephosphorylation of CRTC2.

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