Table 1 Glossary
From: Restrictions to HIV-1 replication in resting CD4+ T lymphocytes
AGS | Aicardi-Goutières syndrome, rare inherited autoimmune, inflammatory disorder caused by non-sense mutations in the samhd1, trex1 or rnaseh2a-c genes |
Cofilin | actin severing factor regulating cellular F-actin polymerization states |
Cortical actin | F-actin layer underneath the plasma membrane providing a physical barrier to virus entry |
CXCR4 | chemokine receptor acting as entry co-receptor for HIV-1 with CXCR4-tropic Env |
HIV | human immunodeficiency virus, causative agent of AIDS |
RT | reverse transcription, characteristic step in the life cycle of retroviruses in which incoming genomic RNA is transcribed into DNA by the viral enzyme reverse transcriptase |
SAMHD1 | sterile alpha motif (SAM) and histidine/aspartic acid (HD) domain-containing protein 1, host cell deoxynucleoside triphosphate (dNTP) triphosphohydrolase |
SIV | simian immunodeficiency virus |
TREX1 | three prime repair exonuclease 1, 3′-5′ cellular exonuclease |
Vpx | viral protein X, encoded by most SIVs and HIV-2 strains, SAMHD1 antagonist |
Vpr | viral protein R, encoded by HIV-1 and some SIV strains |
VSV-G | glycoprotein of the vesicular stomatitis virus; can be incorporated into lentiviral particles to mediate cell entry in a CD4- and CXCR4-independent manner |
