Figure 5
From: Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
A schematic model of the WMM complex function. The WMM complex mediates methylation of internal adenosine residues in eukaryotic mRNA, forming N6-methyladenosine. WTAP binds to the m6A consensus RRACH motif of mRNA and recruits catalytic subunits METTL3 and METTL14. Then the METTL3-METTL14 complex carries out m6A methyltransferase activity in the m6A motif.
