Figure 7
Performance comparison of ccfDNA methylation classifiers, AFP and ALT. For plasma samples of the HCC patients, cirrhosis patients and normal individuals in the training group (n = 72) and the testing group (n = 19) and post-surgery HCC patients (n = 3), detection results of two ccfDNA methylation classifiers, AFP, gamma-glutamyl transferase (GGT) and ALT are shown as positive (black bars, AFP: > 20 ng/ml, GGT: > 60 U/l, ALT: > 50 U/l) versus negative (blue bars). The MCTA-Seq data of the type I and type II markers in the classifiers are shown in a heat map using a Z-score approach (see Materials and Methods). The tumor sizes are also indicated.
