Figure 1
From: ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer
FBW7 is downregulated in pancreatic cancer. (A) Immunoblot analysis of the indicated human pancreatic cancer cell lines. The HPDE cell line was included as a positive control for the detection of endogenous FBW7 expression, and α-tubulin was used as a loading control. (B) IHC staining of human pancreatic adenocarcinoma tissue arrays using specific antibodies for FBW7. T, tumor; ANT, adjacent normal tissues; scale bar, 200 μm; magnification scale bar, 40 μm. (C) Kaplan-Meier analysis of overall survival rate of pancreatic cancer patients according to the expression of FBW7 (n = 86, P = 0.029, log-rank test).
