Figure 7 | Cell Research

Figure 7

From: Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment

Figure 7

Schematic graph depicting the involvement of miR-149 in the interaction between H. pylori-infected gastric epithelial cells and gastric cancer-associated fibroblasts. H. pylori infection induces the secretion of PGE2 by gastric epithelial cells. Stromal PGE2 silences miR-149 probably through the hypermethylation of miR-149. The silence of miR-149 removes the suppression of its target genes, IL-6 and EP2, leading to elevated level of IL-6 that acts on fibroblasts to stimulate the transformation of NF into CAF. Meanwhile, IL-6 induces more aggressive behaviors of malignant gastric epithelial cells.

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