Figure 6 | Cell Research

Figure 6

From: P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy

Figure 6

P2RX7 inhibition reduces the adhesion molecules in brain microvasculature of CLP mice. (A) Adherent leukocytes were decreased in A438079-treated mice versus saline-treated mice 4 h after CLP. The results are shown as the means ± SEM (n = 4). **P < 0.01. (B) The Scatter plots show the cumulative frequency of rolling velocities of leukocytes in each treatment conditions. (C, D) Changes of brain endothelial ICAM-1 and VCAM-1 levels from CLP mice with or without A438079 treatment. Flow cytometry analysis shows the surface staining of ICAM-1 and VCAM-1 in the indicated groups. Data are representative of three independent experiments with four mice per group. (E) The chemokine CXCL1 and CX3CL1 mRNA levels were decreased in CLP mice after A438079 treatment. Data are expressed as means ± SEM (n = 4). *P < 0.05, **P < 0.01.

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