Figure 4
From: Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
Cryo-EM structure of the Sre1-CTD/Scp1-WD40 complex. (A) Cryo-EM imaging of the GraFixed Sre1-CTD/Scp1-WD40 complex. Shown on the left and right are representative micrographs as well as 2D classifications. (B) The overall EM map of the Sre1-CTD and Scp1-WD40 complex. (C) Docking of the crystal structures of Sre1-CTD dimer and Scp1-WD40 into the EM map. The crystal structures of the individual components can be easily docked into the EM map in Chimera. The two protomers in each Sre1-CTD dimer are colored green and blue for visual clarity. The modest resolution does not allow discrimination of any conformational differences between the two protomers within each dimer. See also Supplementary information, Figure S6.
