Figure 5
From: Drugging the undruggables: exploring the ubiquitin system for drug development
PROTAC as an anti-cancer strategy. (A) PROTACs are bifunctional molecules that are comprised of a targeting ligand tethered to an E3 ligase-recruiting moiety through a short linker. (B) dBET1 as an example of PROTAC. dBET1 is comprised of JQ1 that binds to oncoprotein BRD4, and thalidomide that recruits CRL4CRBN, an E3 ubiquitin ligase.
