Figure 7
From: CCAR1 5′ UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance
Diagram of working model. (A) Ago2 facilitates miRNA binding to a linear or structured miRNA-binding site to promote reciprocal functional repression (green arrows) or stabilization (orange arrows), respectively. (B) Molecular crosstalk among CCAR1 5′ UTR, miR-1254 and miR-1254-targeted genes. CCAR1 mRNA increases miR-1254 level, which causes an enhanced repression of miR-1254 target gene expression (orange arrows), while miR-1254 target gene mRNA reduces miR-1254 level, which leads to a repression of CCAR1 mRNA (green arrows).
