Figure 1 | Cell Research

Figure 1

From: Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage

Figure 1

IF protects mice from diet-induced obesity and metabolic dysfunction. (A) Schematic illustration of the 2:1 IF regimen. (B) Body weight measurement during 16 weeks of IF. (C) Changes of energy intake during 16 weeks of IF cycles. The inset shows total energy intake during 16 weeks of IF cycles. (D) Body composition showing fat and lean mass. (E) H&E-stained sections of adipose tissues; IWAT (subcutaneous), PWAT (visceral), and BAT. (F) Average of cross-sectioned area of subcutaneous white adipocytes, revealing reduced white adipocyte size for HFD-IF mice compared to HFD-AL mice. (G) GTT in HFD-AL and HFD-IF mice. The inset shows AUC. (H) ITT. The inset shows AUC. (I) HOMA-IR. Data are expressed as mean ± SEM (ND-AL: n = 7; ND-IF: n = 8; HFD-AL: n = 7; and HFD-IF: n = 8); one or two-way ANOVA with Student-Newman-Keuls post hoc analysis and two-tailed unpaired Student's t-test; *P < 0.05 and **P < 0.01 vs HFD-AL. AL, ad libitum; AUC, area under the curve; HFD, high-fat diet; ND, normal diet.

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