Figure 7 | Cell Research

Figure 7

From: Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage

Figure 7

VEGF expression in human WAT correlates with M2 macrophage and WAT browning. (A) A correlation heatmap of VEGFA gene with unsupervised hierarchical clustering of M1/M2 macrophages- and beige/brown adipocyte-associated genes in human WAT. A histogram of VEGFA gene expression level (RPKM) is shown on the top of the heatmap. (B) Representative scatter plots showing correlation of VEGFA with IL1R1 & ABHD5 (M2), CIDEA & NUDFS2 (beige), and NR3C2 & ITGB7 (M1) genes. (C) Summary of VEGFA correlation with M2, beige, and M1-associated genes. Permutation P-values with the GSEA are shown. (D) Schematic model of IF-mediated VEGF expression underlying adipose thermogenesis and M2 macrophage polarization. GSEA, gene set enrichment analysis.

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