Figure 1
From: De novo DNA methylation during monkey pre-implantation embryogenesis
Global patterns of DNA methylome during monkey pre-implantation development. Averaged levels of DNA methylation at CpG (A) and CpH (B) sites at each stage of monkey early embryogenesis. Unsupervised hierarchical clustering of all filtered CpG (C) and CpH (D) sites in the genomes of sperm, oocytes, and embryos at different pre-implantation stages. Box plots show that with the exception of sperm, we do not observe an inverse relationship between CpG densities and methylation levels at other stages. CpG density was calculated as numbers of CpG sites in consecutive 100-bp tiles (E). (F) Heatmap of methylation levels of CGIs across different developmental stages. 2-c., 2-cell stage; 8-c., 8-cell stage; ICM, inner cell mass at the blastocyst stage; mo., morula stage; oo., oocyte; sp., sperm; zy., zygote.
