Figure 1 | Cell Research

Figure 1

From: Spontaneous DNA damage propels tumorigenicity

Figure 1

Mechanism and consequences of spDSB formation in tumors. spDSBs in cancer cells are generated via a mechanism involving the release from mitochondria of sublethal amounts of ENDOG and CYC1, which in turn unleashes CAD via the activation of CASP3. This is followed by the translocation of ENDOG and CAD from the cytosol to the nucleus, where these nucleases catalyze DNA cleavage. Upon their generation, spDSBs ignite an ATM/NF-κB/STAT3 cascade that promotes malignant tumorigenicity and stemness.

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