Figure 4
From: Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer
Deletion of RAGE protects against pancreatic tumorigenesis in KCH mice. (A) Kaplan-Meier survival analysis was performed in KCH (Pdx1-Cre;K-RasG12D/+;Hmgb1−/−), KCHR (Pdx1-Cre;K-RasG12D/+;Hmgb1−/−;Rage−/−), and KCHT9 (Pdx1-Cre;K-RasG12D/+;Hmgb1−/−;Tlr9−/−) mice (n = 5 mice/treatment, **P < 0.01, log-rank test). (B-G) In parallel, pancreatic lesion formation (B), tumor metastasis/invasion incidence (C), serum IL-6 level (D), and relative expressions of p-ERK1/2 (E), p-AKT (F), and p-STAT3 (G) in the pancreas were assayed. Graphs show means ± sem, *P < 0.05, **P < 0.01 (n = 5 mice/treatment, unpaired t-test).
