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Drug discovery for ageing: SIMPs, NEDs and screening challenges

Drugs that modulate fundamental mechanisms of ageing offer the promise of substantially improving the health of ageing populations, but innovative approaches to identify and evaluate such ‘gerotherapeutics’ are needed.
By
  1. Richard G. A. Faragher

    1. University of Brighton, Brighton, UK.

  2. Richard C. Hartley

    1. University of Glasgow, Glasgow, UK.

Introduction

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Nature Reviews Drug Discovery 23, 725-726 (2024)

doi: https://doi.org/10.1038/d41573-024-00087-3

Acknowledgements

The authors wish to thank the BBSRC and MRC for supporting the BLAST network (BB/W01825X/1) and the overarching UK Ageing Network, Dr James Cole for his advice on early human evolution and especially Dr James Murray of Swansea University for demonstrating the potential value of killifish to the drug discovery process.

References

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Supplementary Information

  1. Supplementary Fig. 1

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