Inner membrane turns inside out to exit mitochondrial organelles

Pla-Martín, David; Reichert, Andreas S.

doi:10.1038/d41586-024-02528-w

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21 August 2024

Inner membrane turns inside out to exit mitochondrial organelles

How do mitochondrial organelles remove damaged parts of inner membrane for recycling in the cytoplasm? The discovery of an exit route that flips inner membrane outside the organelle provides some answers.

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David Pla-Martín
1. David Pla-Martín is at the Institute of Biochemistry and Molecular Biology I, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
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Andreas S. Reichert
1. Andreas S. Reichert is at the Institute of Biochemistry and Molecular Biology I, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
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Organelles such as mitochondria use a variety of mechanisms to recycle their components. Writing in Nature, Prashar et al.¹ report a surprising new twist in how these events can occur.

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Nature 632, 987-988 (2024)

doi: https://doi.org/10.1038/d41586-024-02528-w

References

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The authors declare no competing interests.

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[1] Prashar, A. et al. Nature 632, 1110–1117 (2024).
Article Google Scholar

[2] Picard, M. & Shirihai, O. S. Cell Metab. 34, 1620–1653 (2022).
Article PubMed Google Scholar

[3] Suomalainen, A. & Nunnari, J. Cell 187, 2601–2627 (2024).
Article PubMed Google Scholar

[4] Priault, M. et al. Cell Death Differ. 12, 1613–1621 (2005).
Article PubMed Google Scholar

[5] Lemasters, J. J. Rejuvenation Res. 8, 3–5 (2005).
Article PubMed Google Scholar

[6] Narendra, D., Tanaka, A., Suen, D.-F. & Youle, R. J. J. Cell Biol. 183, 795–803 (2008).
Article PubMed Google Scholar

[7] Kitada, T. et al. Nature 392, 605–608 (1998).
Article PubMed Google Scholar

[8] Valente, E. M. et al. Am. J. Hum. Genet. 68, 895–900 (2001).
Article PubMed Google Scholar

[9] Abudu, Y. P. et al. J. Cell Biol. 220, e202009092 (2021).
Article PubMed Google Scholar

[10] Hammerling, B. C. et al. Nature Commun. 8, 14050 (2017).
Article PubMed Google Scholar

[11] Sen, A. et al. Nature Commun. 13, 6704 (2022).
Article PubMed Google Scholar

[12] Sugiura, A., McLelland, G.-L., Fon, E. A. & McBride, H. M. EMBO J. 33, 2142–2156 (2014).
Article PubMed Google Scholar

[13] Hughes, A. L., Hughes, C. E., Henderson, K. A., Yazvenko, N. & Gottschling, D. E. eLife 5, e13943 (2016).
Article PubMed Google Scholar

[14] Ma, X. et al. Cell Rep. 42, 113291 (2023).
Article PubMed Google Scholar

[15] McArthur, K. et al. Science 359, eaao6047 (2018).
Article PubMed Google Scholar

[16] Tábara, L. C. et al. Cell 187, 3619–3637 (2024).
Article PubMed Google Scholar

[17] Kondadi, A. K. et al. EMBO Rep. 21, e49776 (2020).
Article PubMed Google Scholar

[18] Wolf, D. M. et al. EMBO J. 38, e101056 (2019).
Article PubMed Google Scholar

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