People who lack the immune protein TNF can still fight infection

Pyle, Charlie J.; Tobin, David M.

doi:10.1038/d41586-024-02657-2

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28 August 2024

People who lack the immune protein TNF can still fight infection

The immune-signalling protein TNF has an essential role in inflammatory responses. Two people who were found to have no functional TNF are surprisingly healthy and able to fend off most infections, but are susceptible to tuberculosis.

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Charlie J. Pyle
1. Charlie J. Pyle is in the Department of Molecular Genetics & Microbiology, the Department of Integrative Immunobiology and the Department of Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA.
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David M. Tobin
1. David M. Tobin is in the Department of Molecular Genetics & Microbiology, the Department of Integrative Immunobiology and the Department of Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA.
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Nearly 50 years ago, the key immune-signalling molecule TNF was discovered in mice infected with a microorganism called a mycobacterium¹. Writing in Nature, Arias et al.² now report unexpected findings about TNF’s role in the immune response of humans.

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Nature 633, 293-294 (2024)

doi: https://doi.org/10.1038/d41586-024-02657-2

References

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The authors declare no competing interests.

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[1] Carswell, E. A. et al. Proc. Natl Acad. Sci. USA 72, 3666–3670 (1975).
Article PubMed Google Scholar

[2] Arias, A. A. et al. Nature 633, 417–425 (2024).
Article Google Scholar

[3] Marino, M. W. et al. Proc. Natl Acad. Sci. USA 94, 8093–8098 (1997).
Article PubMed Google Scholar

[4] Keane, J. et al. N. Engl. J. Med. 345, 1098–1104 (2001).
Article PubMed Google Scholar

[5] Bean, A. G. et al. J. Immunol. 162, 3504–3511 (1999).
Article PubMed Google Scholar

[6] Flynn, J. L. et al. Immunity 2, 561–572 (1995).
Article PubMed Google Scholar

[7] Lin, P. L. et al. Arthritis Rheum. 62, 340–350 (2010).
Article PubMed Google Scholar

[8] Clay, H., Volkman, H. E. & Ramakrishnan, L. Immunity 29, 283–294 (2008).
Article PubMed Google Scholar

[9] Tobin, D. M. et al. Cell 148, 434–446 (2012).
Article PubMed Google Scholar

[10] Bekker, L.-G. et al. Infect. Immun. 68, 6954–6961 (2000).
Article PubMed Google Scholar

[11] Bustamante, J. Hum. Genet. 139, 993–1000 (2020).
Article PubMed Google Scholar

[12] Pahari, S. et al. STAR Protoc. 5, 103061 (2024).
Article PubMed Google Scholar

[13] Wiens, K. E. et al. BMC Med. 16, 196 (2018).
Article PubMed Google Scholar

[14] Bottai, D. et al. Nature Commun. 11, 684 (2020).
Article PubMed Google Scholar

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