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Gender-affirming therapy reshapes the immune systems of trans men

Testosterone treatment boosts levels of an inflammatory protein to those typically seen in cis men, study finds.
By
  1. Saima Sidik
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When trans men receive testosterone therapy, their bodies begin to resemble those of cis men in many ways — including their immune systems. That’s according to a study published today in Nature1, one of the largest yet to examine how gender-affirming hormone therapy (GAHT) affects the immune system over time.

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Nature 633, 264-265 (2024)

doi: https://doi.org/10.1038/d41586-024-02869-6

Read the related News & Views: ‘The immune system of trans men reveals how hormones shape immunity’.

References

  1. Lakshmikanth, T. et al. Nature 633, 155–164 (2024).

    Article  Google Scholar 

  2. Cohen, J. & van der Meulen Rodgers, Y. Int. J. Equity Health 22, 261 (2023).

    Article  Google Scholar 

  3. Silva, J. et al. Preprint at medRxiv https://doi.org/10.1101/2024.02.29.24303568 (2024).

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