Francisco Lopera obituary: neurologist who traced genetic origin of early-onset Alzheimer’s

Colombian neurologist Francisco Lopera, who has died aged 73, changed the course of research on Alzheimer’s disease — both with insights into its mechanism and with his personal, family-centred, long-term approach. He met with thousands of people in a single family, parsing their stories to track hereditary dementia. This level of doctor–patient trust became the foundation for a clinical trial in which, for the first time, a single, extensive kindred agreed to participate. He identified a mutation responsible for early-onset Alzheimer’s disease. The size of the family also created the opportunity to detect, in a small number of family members, rare protective genes that can delay the disease onset by decades.

In the vast majority of Alzheimer’s cases, the cause remains unknown. Cases linked to single mutations are rare — but most of what we know about the disease stems from them. By finding such a mutation, present at birth and leading to dementia some 45 years later, Lopera and his colleagues contributed to the hunt for the disease’s biochemical pathways. They also made progress towards a treatment for the disease, which affects more than 10% of people over the age of 65 and is among the leading causes of death globally.

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Lopera was born in the small town of Aragón in northwest Colombia, and trained in medicine at the nearby University of Antioquia in the provincial capital Medellín, where he spent his entire career. At the time, newly qualified doctors had to complete a year of obligatory social service, called rural. Lopera spent it near the border with Panama, where he encountered unusual situations such as vampire bats spreading rabies in children.

In 1982, entering neurology practice in Medellín and always curious about unusual cases, he came across a 47-year-old man with mid-life dementia — a disease present in several generations of the man’s family. For a decade, Lopera and his colleague, psychologist Lucia Madrigal, travelled through the countryside of Antioquia and deep into the barrios (districts) of Medellín, where they heard repeatedly of early-onset memory loss affecting people who, it would turn out, were part of the same family. They assembled a vast family tree, which revealed that, on average, 50% of an affected parent’s offspring developed the disease. This pattern strongly suggested that a mutated gene was responsible.

In 1989, I met Lopera in Bogotá. He showed me the family tree and we instantly began a collaboration that would last for 35 years. Without post-mortem investigation, the cause of the memory loss was unknown. With some difficulty, Lopera persuaded a family to allow such an investigation. A neuropathologist flew to my house in Boston, Massachusetts, with the brain of an affected member of the family who had died. We observed the hallmarks of Alzheimer’s disease — deposits of amyloid-β protein (senile plaques) and tau-protein aggregates inside neurons (neurofibrillary tangles). Lopera went on to establish an invaluable brain bank in Medellín that today has more than 500 brains.