Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • NEWS AND VIEWS

Change of venue: fission-yeast cell-division cues actually initiate in the nucleus

In yeast, the CDK and cyclin proteins that drive cell division activate first in the nucleus — a different location in the cell from where was previously thought.
By
  1. Julia Kamenz

    1. Julia Kamenz is at the Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747AG Groningen, the Netherlands.

  2. James E. Ferrell Jr

    1. James E. Ferrell Jr is in the Department of Chemical and Systems Biology and in the Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA.

The cell cycle — the parade of biochemical and cellular events by which a cell divides to form two daughter cells — is a fundamental aspect of life. Writing in Nature, Kapadia and Nurse1 provide insights into how the timing of cell-cycle events is orchestrated in the fission yeast Schizosaccharomyces pombe. The authors report that a key cell-cycle regulator is activated first in the nucleus and only later in the cytoplasm.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Nature 643, 1199-1201 (2025)

doi: https://doi.org/10.1038/d41586-025-01712-w

References

  1. Kapadia, N. & Nurse, P. Nature 643, 1391–1399 (2025).

    Article  Google Scholar 

  2. Coudreuse, D. & Nurse, P. Nature 468, 1074–1079 (2010).

    Article  PubMed  Google Scholar 

  3. Basu, S., Greenwood, J., Jones, A. W. & Nurse, P. Nature 607, 381–386 (2022).

    Article  PubMed  Google Scholar 

  4. Stern, B. & Nurse, P. Trends Genet. 12, 345–350 (1996).

    Article  PubMed  Google Scholar 

  5. Swaffer, M. P., Jones, A. W., Flynn, H. R., Snijders, A. P. & Nurse, P. Cell 167, 1750–1761 (2016).

    Article  PubMed  Google Scholar 

  6. Solomon, M. J., Glotzer, M., Lee, T. H., Philippe, M. & Kirschner, M. W. Cell 63, 1013–1024 (1990).

    Article  PubMed  Google Scholar 

  7. Pomerening, J. R., Kim, S. Y. & Ferrell, J. E. Jr Cell 122, 565–578 (2005).

    Article  PubMed  Google Scholar 

  8. Kamenz, J., Gelens, L. & Ferrell, J. E. Jr Curr. Biol. 31, 794–808 (2021).

    Article  PubMed  Google Scholar 

  9. Maryu, G. & Yang, Q. Cell Rep. 41, 111870 (2022).

    Article  PubMed  Google Scholar 

  10. Russell, P. & Nurse, P. Cell 49, 559–567 (1987).

    Article  PubMed  Google Scholar 

  11. Novak, B. & Tyson, J. J. J. Theor. Biol. 165, 101–134 (1993).

    Article  Google Scholar 

  12. Ferrell, J. E. Jr Systems Biology of Cell Signaling: Recurring Themes and Quantitative Models (CRC, 2021).

    Google Scholar 

  13. Lin, M., Xie, S. S. & Chan, K. Y. Cell Div. 17, 1 (2022).

    Article  PubMed  Google Scholar 

  14. Jackman, M., Lindon, C., Nigg, E. A. & Pines, J. Nature Cell Biol. 5, 143–148 (2003).

    Article  PubMed  Google Scholar 

  15. Sha, W. et al. Proc. Natl Acad. Sci. USA 100, 975–980 (2003).

    Article  PubMed  Google Scholar 

  16. Pomerening, J. R., Sontag, E. D. & Ferrell, J. E. Jr Nature Cell Biol. 5, 346–351 (2003).

    Article  PubMed  Google Scholar 

  17. Nolet, F. E. et al. eLife 9, e52868 (2020).

    Article  PubMed  Google Scholar 

  18. Afanzar, O., Buss, G. K., Stearns, T. & Ferrell, J. E. Jr eLife 9, e59989 (2020).

    Article  PubMed  Google Scholar 

Download references

Competing Interests

The authors declare no competing interests.

Subjects

Latest on:

Nature Careers

Jobs

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Advanced search

Quick links