Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • CLINICAL BRIEFINGS

Personalized mRNA vaccine induces strong, durable immunity in hard-to-treat breast cancer

In an experimental trial, a personalized mRNA vaccine was tested in 14 individuals with an aggressive form of breast cancer. It trained immune cells to target cancer-specific mutant proteins, inducing strong, lasting immunity. Ten participants remained disease-free. Analysis of relapses revealed resistance mechanisms, offering essential insights for future therapies.

This is a summary of: Sahin, U. et al. Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC. Nature https://doi.org/10.1038/s41586-025-10004-2 (2026).

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

doi: https://doi.org/10.1038/d41586-026-00477-0

Figure 1 is published under a CC BY 4.0 licence.

References

  1. Li, X. et al. Breast Cancer Res. Treat. 161, 279–287 (2017).

    Article  PubMed  Google Scholar 

  2. Sahin, U. et al. Nature 547, 222–226 (2017).

    Article  PubMed  Google Scholar 

  3. Vormehr, M. et al. Annu. Rev. Med. 70, 395–407 (2019).

    Article  PubMed  Google Scholar 

  4. Rojas, L. A. et al. Nature 618, 144–150 (2023).

    Article  PubMed  Google Scholar 

  5. Kranz, L. M. et al. Nature 534, 396–401 (2016).

    Article  PubMed  Google Scholar 

Download references

Subjects

Latest on:

Nature Careers

Jobs

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Advanced search

Quick links