Table 2 Effect of increasing dose of AA supplement on serum protein N-glycosylation

From: An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects

Glycans

Dose alone

Dose adjusted for time

 

Coefficient

P-value

Coefficient

P-value

G0a

1.124

0.1

0.993

0.09

G0Fa

0.996

0.9

1.020

0.6

G1b

−0.133

0.001

−0.130

0.02

G1Fa

0.962

0.3

1.016

0.7

G2b

−0.976

<0.001

−0.690

0.005

G2Fb

−0.226

0.001

−0.170

0.2

A1b

0.532

0.007

0.669

0.1

A2a

1.082

0.002

1.083

0.005

  1. Abbreviations: AA, Advanced Ambrotose powder; A1, monosialylated; A2, disialylated; F, fucosylated; G0, agalactosylated; G1, monogalactosylated; G2, digalactosylated.
  2. For the purposes of statistical analysis, log transformation was applied to those glycans that exhibited a skewed distribution (more variable at high levels than at low levels).
  3. Regression analysis of the data demonstrates significant dose effects for G1, G2 and A2 serum protein N-glycans.
  4. aAnalysed on logarithmic scale; coefficient=factor by which mean sugar is multiplied per week.
  5. bAnalysed on natural scale; coefficient=increase in mean sugar per week.
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