Table a1 Summary table of the items included in this review

From: A narrative review of recent progress in understanding the relationship between tuberculosis and protein energy malnutrition

Reference

Paper

Methodology

Protein status Indicator

29

Chan et al.29

Experimental Study Murine intervention model

Referred to PEM. Experimental mice developed PEM on 2% of protein diet.

13

Kennedy et al.13

Prospective Cohort Study, 148 (TB) adults, Tanzania

BMI

26

Macallan26

Expert narrative review

Wasting: reduced BMI, TSF thickness and AMC. Metabolic impairment.

20

Schwenk and Macallan20

Expert narrative review

BMI; referred to PEM and wasting.

15

Zachariah et al.15

Prospective Cohort Study, 1181 (TB) adults, rural Malawi

BMI

21

Boelart and Gordeuk21

Expert opinion (Lancet)

Referred to PEM

32

Sushama Bai and Lekshmi Devi32

Prospective Cohort Study, 95 (TB) children, India

Indian Academy of Paediatrics (IAP) classification of PEM

34

Van Lettow et al.34

Expert narrative review

Serum albumin concentrations and total protein

31

Compher31

Expert narrative review (textbook chapter)

Referred to PEM

24, 25

Cegielski and McMurray24

Expert narrative reviews (textbook chapter (2005))

BMI, TSF, MUAC, purified protein derivative (PPD) test; referred to PEM

23

Pelly et al.23

Cross-sectional Study, 212 adults (+15 years), rural and urban Peru

Corrected (bone-free) arm muscle area (CAMA)

28

Cegielski and Demeshlaira28

Expert narrative review (textbook chapter)

Referred to PEM

19

Villamor et al.19

Cross-sectional Study, 2231 (TB) adults, Tanzania

BMI, MUAC, TSF thickness AMC, BIA, total lymphocyte count (TLC) and serum albumin concentration

22

Schaible and Kaufmann22

Expert narrative review

Referred to PEM

14

Dodor14

Prospective Cohort Study, 570 (TB) adults, Ghana

BMI

27

Kim et al.27

Retrospective Cohort Study, 56 (TB) adults, South Korea

Nutritional Risk Score: BMI, serum albumin, serum cholesterol, TLC

30

Ishikawa et al.30

Experimental Study Murine intervention model

Referred to PCM. Experimental mice became undernourished on restricted diet

17

Siddiqui et al.17

Cross-sectional Study, 160 (TB) children (<15 years), Pakistan

Modified Gomez classification

35

Kim et al.35

Case–control Study, 23 TB cases and 23 healthy controls, South Korea

%ideal weight, BMI, serum albumin, TLC, cholesterol and haemoglobin

7

Sinclair et al.7

Systematic review, 6 protein-energy RCTs

Referred to PEM

18

Podewils et al.18

Retrospective Cohort Study, 995 (MDR-TB) adults, Latvia

BMI

16

Mupere et al.16

Retrospective Cohort Study, 747 (TB) adults, Uganda

BMI and fat/lean tissue mass (from BIA)

  1. Abbreviations: AMC, arm muscle circumference; BIA, biological impedance analysis; BMI, body mass index; MUAC, mid-upper arm circumference; MDR-TB, multidrug-resistant TB; PCM, protein calorie malnutrition; PEM, Protein energy malnutrition; RCTs, randomised controlled trials; TSF, triceps skin-fold.