Table 2 Maternal genotypes at SNPs in iron-related genes and Hb levels measured early in pregnancy adjusted by gestational age at the time of measurement
Genotype | Mean | s.d | N | Coefficient | s.e | Adj P-value | % Variance explained |
|---|---|---|---|---|---|---|---|
rs1799945 HFE | |||||||
GG | 12.5 | 0.9 | 144 | –0.093 | 0.023 | 4.1 × 10−5 | 0.19 |
CG | 12.4 | 1.0 | 1532 | ||||
CC | 12.3 | 1.0 | 4731 | ||||
rs1800562 HFE | |||||||
AA | 12.6 | 1.1 | 29 | –0.174 | 0.032 | 4.6 × 10−8 | 0.34 |
GA | 12.5 | 1.0 | 828 | ||||
GG | 12.3 | 1.0 | 5541 | ||||
rs3811647 TF | |||||||
GG | 12.3 | 1.0 | 2766 | –0.007 | 0.017 | 0.69 | 0.00 |
GA | 12.3 | 1.0 | 2885 | ||||
AA | 12.3 | 0.9 | 717 | ||||
rs4820268 TMPRSS6 | |||||||
AA | 12.4 | 1.0 | 1721 | –0.103 | 0.016 | 3.6 × 10−10 | 0.55 |
AG | 12.3 | 1.0 | 3316 | ||||
GG | 12.2 | 1.0 | 1351 | ||||
rs1799945/rs1800562 | |||||||
2 risk alleles | 12.6 | 1.0 | 297 | –0.136 | 0.020 | 4.9 × 10−12 | 0.56 |
3 risk alleles | 12.4 | 1.0 | 2080 | ||||
4 risk alleles | 12.3 | 1.0 | 3931 | ||||
Genotypic score | |||||||
⩽3 risk alleles | 12.5 | 1.0 | 822 | –0.113 | 0.013 | 3.0 × 10−18 | 1.02 |
4 risk alleles | 12.4 | 1.0 | 2093 | ||||
5 risk alleles | 12.3 | 1.0 | 2462 | ||||
6 risk alleles | 12.2 | 1.0 | 844 | ||||
