Table 3 Proportion of mothers taking iron supplements at 18 or 32 weeks of pregnancy according to their genotype at iron-related SNPs
dbSNP | Gene | Genotype | Not taking supplements (%) | Taking supplements at 18 weeks (%) | Taking supplements at 32 weeks (%) | P-value |
|---|---|---|---|---|---|---|
rs1799945 | HFE | GG | 63 (48.8) | 42 (32.6) | 24 (18.6) | 0.11 |
CG | 676 (46.7) | 433 (29.9) | 339 (23.4) | |||
CC | 1927 (43.4) | 1390 (31.3) | 1123 (25.3) | |||
rs1800562 | HFE | AA | 17 (65.4) | 5 (19.2) | 4 (15.4) | 0.04 |
GA | 367 (47.9) | 230 (30.0) | 169 (22.1) | |||
GG | 2285 (43.8) | 1623 (31.1) | 1307 (25.1) | |||
rs3811647 | TF | GG | 1117 (43.2) | 787 (30.4) | 681 (26.3) | 0.04 |
GA | 1244 (45.7) | 851 (31.3) | 624 (23.0) | |||
AA | 283 (42.0) | 218 (32.3) | 173 (25.7) | |||
rs4820268 | TMPRSS6 | AA | 759 (47.4) | 481 (30.1) | 360 (22.5) | 0.01 |
AG | 1378 (44.1) | 969 (31.0) | 780 (24.9) | |||
GG | 521 (40.9) | 415 (32.6) | 339 (26.5) | |||
rs1799945/rs1800562 | 2 risk alleles | 0 | 144 (53.1) | 77 (28.4) | 50 (18.5) | 0.001 |
3 risk alleles | 1 | 907 (46.4) | 591 (30.3) | 455 (23.3) | ||
4 risk alleles | 2 | 1580 (42.7) | 1164 (31.5) | 955 (25.8) | ||
genotypic score | ⩽3 risk alleles | 0 | 391 (51.4) | 217 (28.6) | 152 (20.0) | <0.001 X2=29.66 6 df |
4 risk alleles | 1 | 897 (45.7) | 608 (31.0) | 456 (23.3) | ||
5 risk alleles | 2 | 982 (42.2) | 725 (31.1) | 621 (26.7) | ||
6 risk alleles | 3 | 325 (40.8) | 262 (32.9) | 210 (26.3) |
