Table 4 Maternal education levels according to genotype at iron-related SNPs
dbSNP | Gene | Genotype a | <O level (%) | O level (%) | >O level (%) | Unadjusted OR (95% CI) P-value N | Adjustedb OR (95% CI) P-value N |
|---|---|---|---|---|---|---|---|
rs1799945 | HFE | GG | 30 (22.4) | 40 (29.8) | 64 (47.8) | 0.89 (0.81, 0.98) 0.01 6152 | 0.89 (0.80, 0.99) 0.03 4535 |
CG | 418 (28.3) | 540 (36.6) | 518 (35.1) | ||||
CC | 1378 (30.4) | 1600 (35.2) | 1564 (34.4) | ||||
rs1800562 | HFE | AA | 8 (28.6) | 9 (32.1) | 11 (39.3) | 1.00 (0.88, 1.14) 1.00 6139 | 0.99 (0.85, 1.15) 0.89 4521 |
GA | 259 (32.7) | 237 (29.9) | 296 (37.4) | ||||
GG | 1553 (29.2) | 1928 (36.3) | 1838 (34.5) | ||||
rs3811647 | TF | GG | 803 (30.1) | 954 (35.8) | 905 (34.0) | 1.08 (1.01, 1.16) 0.03 6112 | 1.10 (1.01, 1.19) 0.03 4517 |
GA | 829 (29.9) | 971 (35.0) | 971 (35.0) | ||||
AA | 184 (27.1) | 226 (33.3) | 269 (39.6) | ||||
rs4820268 | TMPRSS6 | AA | 506 (30.9) | 567 (34.6) | 566 (34.5) | 1.03 (0.97, 1.10) 0.34 6133 | 1.03 (0.95, 1.11) 0.45 4533 |
AG | 924 (29.0) | 1153 (36.1) | 1115 (34.9) | ||||
GG | 383 (29.4) | 453 (34.8) | 466 (35.8) | ||||
rs1799945/rs1800562 | HFE | 2 risk alleles | 81 (28.8) | 80 (28.5) | 120 (42.7) | 0.92 (0.85, 0.99) 0.04 6055 | 0.91 (0.83, 1.00) 0.05 4465 |
3 risk alleles | 581 (29.1) | 708 (35.4) | 710 (35.5) | ||||
4 risk alleles | 1135 (30.1) | 1359 (36.0) | 1281 (33.9) | ||||
genotypic score | HFE-TMPRSS6 | ⩽3 risk alleles | 241 (30.6) | 249 (31.9) | 294 (37.5) | 0.99 (0.94, 1.04) 0.61 5974 | 0.98 (0.92, 1.04) 0.54 4417 |
4 risk alleles | 591 (29.5) | 724 (36.2) | 687 (34.3) | ||||
5 risk alleles | 684 (28.8) | 872 (36.7) | 818 (34.5) | ||||
6 risk alleles | 252 (30.9) | 279 (34.3) | 283 (34.8) |
