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Pharmacokinetics of daily versus monthly vitamin D3 supplementation in non-lactating women

European Journal of Clinical Nutrition volume 68, pages 632–634 (2014)Cite this article

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Abstract

This study compared serum cholecalciferol and 25-hydroxyvitamin D (25(OH)D) concentrations over four weeks in healthy, non-pregnant, non-lactating females aged 18–40 years, who were randomized to oral cholecalciferol 5000 international units (IU) daily for 28 days or a single dose of 150 000 IU. The study was conducted in Rochester, MN in March and April of 2010. We found no difference in mean 25(OH)D between treatment groups on study day 0 or day 28 (P=0.14 and 0.28, respectively). The daily group had 11 more days of detectable serum cholecalciferol than the single-dose group (P<0.001). There was no difference observed in cholecalciferol area under the curve (AUC28) between groups (P=0.49). However, the single-dose group had a significantly greater mean 25(OH)D AUC28 compared with the daily group (P<0.001).

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Acknowledgements

This project was supported by NIH/NCRR CTSA Grant Number UL1 RR024150. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. This study was partially funded by a research grant from the Mayo Clinic Pharmacy Services Discretionary Fund.

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Author notes

  1. M E Meekins

    Present address: 7Current address: Department of Pharmacy, Mayo Clinic Health System, Mankato, MN, USA.,

  2. B R Lee

    Present address: 8Current address: Department of Pharmacy Services, University of Kentucky, Lexington, KY, USA.,

  3. B M Gardner

    Present address: 9Current address: Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.,

Authors and Affiliations

  1. Department of Pharmacy, Mayo Clinic, Rochester, MN, USA

    M E Meekins, B R Lee & B M Gardner

  2. Department of Family Medicine, Mayo Clinic, Rochester, MN, USA

    S S Oberhelman & T D Thacher

  3. Department of Biostatistics and Informatics, Mayo Clinic, Rochester, MN, USA

    S S Cha

  4. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

    R J Singh

  5. Department of Paediatrics, Developmental Pathways for Health Research Unit, University of Witwatersrand, Johannesburg, South Africa

    J M Pettifor

  6. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA

    P R Fischer

Authors
  1. M E Meekins
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  2. S S Oberhelman
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  3. B R Lee
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  4. B M Gardner
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  9. T D Thacher
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Corresponding author

Correspondence to M E Meekins.

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The authors declare no conflict of interest.

Additional information

Initial results of this study were presented at the poster sessions at the American Society for Nutrition (ASN) Advances and Controversies in Clinical Nutrition Conference held February 25–27, 2011 in San Francisco, CA.

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Meekins, M., Oberhelman, S., Lee, B. et al. Pharmacokinetics of daily versus monthly vitamin D3 supplementation in non-lactating women. Eur J Clin Nutr 68, 632–634 (2014). https://doi.org/10.1038/ejcn.2013.278

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  • DOI: https://doi.org/10.1038/ejcn.2013.278

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