Abstract
A recent investigation reported, for the first time, an association between variants in the IFIH1-GCA-KCNH7 locus and multiple sclerosis (MS). We sought to replicate this genetic association in MS with a new independent MS cohort composed of French Caucasian MS trio families. The two most significant IFIH1 single nucleotide polymorphisms, rs1990760 and rs2068330, reported as involved in MS susceptibility, were genotyped in 591 French Caucasian MS trio families, and analyzed using the transmission/disequilibrium test. No association with MS was found (rs1990760, P=0.45 and rs2068330, P=0.27). Similarly, no significant association was detected after stratification for HLA-DRB1*1501 carriers. Reasons that may explain this discrepancy between the original report and our study are discussed.
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Acknowledgements
We thank the French MS genetics Network REFGENSEP for their help and support. This work could not have been carried out without the SNP technology performed in the genomic platform of Genopole Toulouse Midi Pyrénées. The financial support of ARSEP (Association pour la recherche sur la Sclérose en plaques) is acknowledged.
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Couturier, N., Gourraud, PA., Cournu-Rebeix, I. et al. IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients. Eur J Hum Genet 17, 844–847 (2009). https://doi.org/10.1038/ejhg.2008.259
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DOI: https://doi.org/10.1038/ejhg.2008.259
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