Abstract
Herbert et al reported association with obesity of a common DNA variant rs7566605 at 10 kb upstream of the INSIG2 gene. We analyzed rs7566605 polymorphism in 3125 Chinese in a cross-sectional study. We found no significant association of rs7566605 polymorphism with body mass index (BMI) and waist circumference among all participants (P=0.52). However, if geographic location is considered, the C/C genotype of rs7566605 was marginally associated with increased levels of BMI and risk of obesity among individuals living in Shanghai (P=0.06), indicating that the C/C genotype may contribute to obesity in certain subpopulation among Chinese under certain environmental settings.
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Acknowledgements
This work was supported by research grants from Chinese Academy of Sciences (One Hundred Talents Program and the Knowledge Innovation Program KSCX1-YW-02), National Natural Science Foundation of China (30470870 and 30588002) and Ministry of Science and Technology of China (2006CB503900 and 2007CB947100) to YC.
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Yang, L., Wu, Y., Li, H. et al. Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation. Eur J Hum Genet 16, 759–761 (2008). https://doi.org/10.1038/ejhg.2008.8
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DOI: https://doi.org/10.1038/ejhg.2008.8
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