Figure 1
From: Caveolinopathies: from the biology of caveolin-3 to human diseases
Cav-3 is synthesized in the endoplasmic reticulum (ER) and is then transported to the Golgi complex as detergent-soluble oligomers. When Cav-3 exits the Golgi complex, the oligomers associate with glycosphingolipid and cholesterol-enriched lipid-raft domains, as judged by detergent-resistant membrane (DRM) association, and forms the caveolar carriers. These complexes finally fuse with the plasma membrane defining the caveolae invaginations.
