Figure 1
From: Study of smell and reproductive organs in a mouse model for CHARGE syndrome
Immunohistochemistry showed that Chd7 protein is present in olfactory epithelium and in areas of the brain involved in olfaction and reproduction in wild-type C3HeB/FeJ mice. (a) At E12.5 and (b) E14.5, Chd7 is present in the olfactory epithelium and olfactory bulb (sagittal sections). (c–f) At E16.5, Chd7 is present in the vomeronasal organ and olfactory epithelium, olfactory bulb, hypothalamus and pituitary (coronal sections). (d) Chd7 expression is most prominent in the basal cells and olfactory sensory neurons. Scale bars=500 μm (a and b); 100 μm (c, e and f); 50 μm (d). bc, basal cells; hypo, hypothalamus; ns, nasal septum; ob, olfactory bulb; oe, olfactory epithelium; osn, olfactory sensory neurons; pit, pituitary; rp, Rathke's pouch; ssc, supportive sustentacular cells; to, tongue; and vno, vomeronasal organ.
