Table 1 Impact of misclassification between schizophrenia (disorder A) and bipolar disorder (disorder B) on estimation of genetic parameters from recurrence risks in first-degree relatives

From: Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes

    

rgT=0

rgT=0.25

rgT=0.5

M TA

M TB

K DA

K D

h 2 DA

h 2 DB

r gD

h 2 DA

h 2 DB

r gD

h 2 DA

h 2 DB

r gD

 0

0

1.00

1.00

76

76

0

76

76

25

76

76

50

 5

5

1.00

1.00

72

72

21

73

73

39

74

74

59

10

10

1.00

1.00

68

68

37

69

69

51

71

71

67

15

15

1.00

1.00

65

65

50

66

66

61

69

69

74

20

20

1.00

1.00

62

62

62

64

64

70

67

67

80

30

30

1.00

1.00

56

56

82

59

59

86

63

63

91

40

40

1.00

1.00

52

52

95

56

56

96

61

61

98

50

50

1.00

1.00

51

51

100

55

55

100

60

60

100

 0

5

1.05

0.95

74

75

11

74

75

32

75

75

54

 0

10

1.10

0.90

71

74

20

72

74

38

74

74

58

 0

15

1.15

0.85

69

73

28

71

73

44

73

73

62

 0

20

1.20

0.80

67

71

34

69

71

48

72

71

65

 0

30

1.30

0.70

65

69

45

67

69

57

71

69

70

  1. Parameters follow those used in Table 3 of Kendler.5 All values are expressed as percentages. The true disease prevalences are assumed to be 1% for both schizophrenia and bipolar disorder, KTA=KTB=1%. True recurrence risks to first-degree relatives are λTA=λTB=8.0. These parameters equate to true heritabilities on the liability scale of hTA2=hTB2=0.76. MTA is the proportion of true schizophrenia cases misclassified as bipolar disorder and MTB is the proportion of true bipolar disorder cases misclassified as schizophrenia. The true genetic correlation between the disorders is rgT=0, 0.25,0.5. The estimated parameters based on diagnosed prevalences and recurrences risks have subscript D.
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