Table 2 Impact of misclassification between schizophrenia (disorder A) and brief psychotic disorder (disorder B) on estimation of genetic parameters from recurrence risks in first-degree relatives
rgT=0 | rgT=0.25 | rgT=0.5 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
M TA | M TB | K DA | K D | h 2 DA | h 2 DB | r gD | h 2 DA | h 2 DB | r gD | h 2 DA | h 2 DB | r gD |
0 | 0 | 1.00 | 1.00 | 76 | 21 | 0 | 76 | 21 | 25 | 76 | 21 | 50 |
5 | 5 | 1.00 | 1.00 | 72 | 20 | 25 | 72 | 21 | 44 | 73 | 21 | 63 |
10 | 10 | 1.00 | 1.00 | 68 | 19 | 45 | 69 | 20 | 59 | 69 | 22 | 73 |
15 | 15 | 1.00 | 1.00 | 64 | 19 | 62 | 65 | 21 | 72 | 66 | 23 | 82 |
20 | 20 | 1.00 | 1.00 | 60 | 20 | 75 | 61 | 22 | 81 | 62 | 25 | 88 |
30 | 30 | 1.00 | 1.00 | 51 | 23 | 91 | 53 | 26 | 93 | 55 | 29 | 96 |
0 | 5 | 1.05 | 0.95 | 73 | 21 | 3 | 74 | 21 | 27 | 74 | 21 | 51 |
0 | 10 | 1.10 | 0.90 | 71 | 21 | 6 | 71 | 21 | 29 | 72 | 21 | 52 |
0 | 15 | 1.15 | 0.85 | 68 | 20 | 9 | 69 | 20 | 31 | 70 | 20 | 54 |
0 | 20 | 1.20 | 0.80 | 66 | 20 | 12 | 67 | 20 | 33 | 68 | 20 | 55 |
0 | 30 | 1.30 | 0.70 | 62 | 19 | 17 | 63 | 19 | 37 | 65 | 19 | 57 |
5 | 0 | 0.95 | 1.05 | 75 | 20 | 22 | 75 | 21 | 41 | 75 | 22 | 61 |
10 | 0 | 0.90 | 1.10 | 74 | 20 | 38 | 74 | 21 | 54 | 74 | 22 | 70 |
15 | 0 | 0.85 | 1.15 | 73 | 20 | 52 | 73 | 22 | 64 | 73 | 24 | 77 |
20 | 0 | 0.80 | 1.20 | 71 | 20 | 63 | 71 | 22 | 72 | 71 | 25 | 82 |
30 | 0 | 0.70 | 1.30 | 69 | 22 | 77 | 69 | 25 | 83 | 69 | 28 | 89 |