Table 3 Impact of misclassification between schizophrenia (disorder A)and delusional disorder (disorder B) on estimation of genetic parameters from recurrence risks in first-degree relatives

From: Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes

    

rgT=0

rgT=0.25

rgT=0.5

M TA

M TB

K DA

K D

h 2 DA

h 2 DB

r gD

h 2 DA

h 2 DB

r gD

h 2 DA

h 2 DB

r gD

0

0

1.00

0.10

76

13

0

76

13

25

76

13

50

1

1

0.99

0.11

76

12

39

76

13

54

76

14

70

2

2

0.98

0.12

76

12

63

76

13

72

76

15

82

3

3

0.97

0.13

75

13

77

75

15

83

75

16

89

5

5

0.96

0.15

75

16

91

75

18

93

75

20

95

1

10

1.00

0.10

75

12

42

76

12

57

76

13

72

2

20

1.00

0.10

75

12

71

75

13

78

75

15

85

3

30

1.00

0.10

74

14

87

74

16

90

74

18

93

0

10

1.01

0.09

76

13

1

76

13

25

76

13

50

0

20

1.02

0.08

75

12

1

75

12

26

75

12

51

0

50

1.05

0.05

73

12

3

74

12

27

74

12

51

1

0

0.99

0.11

76

12

39

76

13

54

76

14

70

2

0

0.98

0.12

76

12

62

76

13

72

76

15

81

5

0

0.95

0.15

75

16

90

75

18

92

75

20

94

  1. Parameters follow those used in Table 6 of Kendler.5 All values are expressed as percentages. The true disease prevalences are assumed to be 1% for schizophrenia and 0.1% delusional disorder, KTA=1% and KTB=0.1%. True recurrence risks to first-degree relatives are λTA,= 8.0, λTB=2.0. These parameters equate to true heritabilities on the liability scale of h2TA=0.76 and h2TB=0.13. MTA is the proportion of true schizophrenia cases misclassified as delusional disorder and MTB is the proportion of true delusional disorder cases misclassified as schizophrenia. The true genetic correlation between the disorders is rgT=0, 0.25,0.5. The estimated parameters based on diagnosed prevalences and recurrences risks have subscript D.
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