Table 1 Simulated and expected power for alpha equal to 5 × 10−8 and different levels of frequency P, slope β and correlation ρ

From: SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits

Parameters

Simulated power

Expected power

P

β

ρ

Single

Average

SHAVE

Single

Average

SHAVE

0.10

0.20

0.20

0.0028

0.0103

0.0185

0.0028

0.0103

0.0185

0.10

0.20

0.50

0.1137

0.2114

0.2406

0.1147

0.2129

0.2419

0.10

0.25

0.20

0.0179

0.0628

0.1066

0.0181

0.0629

0.1070

0.10

0.25

0.50

0.4437

0.6429

0.6872

0.4467

0.6456

0.6892

0.10

0.30

0.20

0.0772

0.2279

0.3447

0.0777

0.2283

0.3451

0.10

0.30

0.50

0.8226

0.9371

0.9531

0.8257

0.9391

0.9546

0.50

0.20

0.20

0.1640

0.4118

0.5648

0.1657

0.4131

0.5655

0.50

0.20

0.50

0.9495

0.9899

0.9935

0.9509

0.9902

0.9937

0.50

0.25

0.20

0.5581

0.8630

0.9430

0.5617

0.8634

0.9426

0.50

0.25

0.50

0.9997

1.0000

1.0000

0.9997

1.0000

1.0000

0.50

0.30

0.20

0.8987

0.9923

0.9987

0.9008

0.9922

0.9986

0.50

0.30

0.50

1.0000

1.0000

1.0000

1.0000

1.0000

1.0000

  1. There were 1 million simulations for each combination of P, β and ρ. Expected power is estimated based on equations 5 and 6.
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