Figure 1
From: CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine
The CLCA gene cluster. The display shows the location of microsatellite markers within the CLCA gene cluster6 and the surrounding genomic area (a) and the customized SNP map with a total of 17 diallelic markers (b, d) used for fine-mapping. Marker D1S551 is also known as COPD11 (Chronic obstructive pulmonary disease QTL 11).15 SNPs rs2791476, rs11807298, rs11807638 and rs113894048 in the CLCA4 promotor area (d) were identified after sequencing of contrasting haplotypes (see text for details). Please note the change in scale by several orders of magnitude from A to D. CLCA haplotype blocks (c) were visualized using Haploview.16
