Figure 1
From: Does germ-line deletion of the PIP gene constitute a widespread risk for cancer?
PIP-São Paulo microdeletion at 7q34, detected by array-CGH in cancer patients. Array-CGH profile of a chromosome region at 7q34 (microarray platform Agilent 180K—Agilent Technologies, Santa Clara, CA, USA), showing heterozygous losses of a similar genomic segment (green bars) (image adapted from the Genomic Workbench software, Agilent Technologies): (a) Patient 1; (b) Patient 2; (c) Patient 3; (d) Patient 4 and (e) Y87 (TP53-mutated patient who was not part of the cohorts). In the chromosome 7 ideogram, the red bar marks the microdeletion area, which is showed in detail underneath. The deleted segment (solid green bar) is shown in the context of the genomic region. UCSC genes are also represented (figure adapted from UCSC Genome Bioinformatics, http://genome.ucsc.edu, GRCh37).
