Table 3 Detailed results of the significant KCCA gene–gene coassociations for analysis of ovarian cancer risk of significant (lFDR≤0.05) gene–gene interactions from FOCI analysis ranked by estimated lFDR

From: Kernel canonical correlation analysis for assessing gene–gene interactions and application to ovarian cancer

  

KCCA

CCA

Gene 1

Gene 2

P-value

lFDR

P-value

CASP8

MAP3K3

0.0875

0.0074

14.2897

<1.00E–16

3.38E–21

−0.7248

0.46853

IL1A

IL1B

1.7243

1.9167

−12.8110

<1.00E–16

1.58E–15

−0.0938

0.92525

MAP3K3

TAB1

0.0976

0.0196

8.1708

2.22E–16

8.53E–06

−0.2205

0.82548

MAPK8

PELI3

0.1146

0.0462

8.2271

2.22E–16

7.11E–06

−0.0947

0.92449

AZI2

IKBKB

0.1049

0.0344

9.2402

<1.00E–16

5.65E–08

0.2640

0.79171

TBKBP1

TLR10

0.0436

0.0989

−6.8641

6.69E–12

0.008161

−0.1386

0.88972

HEXIM1

MYD88

0.1073

0.0524

6.8256

8.75E–12

0.001646

−0.3888

0.69736

PIK3CB

TAB1

0.1025

0.0317

10.6548

<1.00E–16

2.59E–11

−0.2520

0.80098

BIRC3

MAP3K3

0.0763

0.0194

5.7655

8.14E–09

0.028977

0.7772

0.43702

MAP3K1

TRAF7

0.1125

0.0465

5.5000

3.80E–08

0.049916

−1.0316

0.30223

BIRC3

TNFRSF13C

0.0601

0.0001

10.8523

<1.00E–16

8.74E–12

−0.1986

0.84251

MAP3K1

MAP3K8

0.1032

0.0377

6.1801

6.41E–10

0.010925

0.3529

0.72412

PYCARD

TAF4

0.0231

0.1012

−6.5902

4.39E–11

0.016345

0.0313

0.97502

  1. Abbreviations: CCA, canonical correlation analysis; FOCI, Follow-up Ovarian Cancer Genetic Association and Interaction Studies; KCCA, kernelized version of CCA; lFDR, local false discovery rate.
  2. Includes the Fisher-transformed maximal kernel canonical correlation values for cases and controls, the resulting test statistic, P-values, and lFDR estimates for KCCA, as well as results for the CCA analysis.
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