Table 1 Mean degree of ICR1 methylation in the first, second and third generations with 95% confidence intervals (parentheses)

From: Evidence for anticipation in Beckwith–Wiedemann syndrome

 

MLPA-test

Bisulphite sequencing

1. generation (n=2)

0.48 (0.45–0.51)

0.47 (0.39–0.55)

2. generation (n=3)

0.71 (0.66–0.76)

0.75 (0.72–0.78)

3. generation (n=3)

0.84 (0.81–0.87)

0.86 (0.81–0.91)

  1. Abbreviations: ICR1, imprinting control region; MLPA, multiplex ligation-dependent probe amplification.
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