Abstract
Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.
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Appendix
Appendix
Members of the SYSGENET network
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1
Penelope Andreux, Ecole Polytechnique Fédérale de Lausanne, AI 1351—Station 15, 1015 Lausanne, Switzerland
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2
Ana Maria Aransay, CIC bioGUNE & CIBERehd, Bizkaia Tecnology Park, Building 801-A, 48160 Derio, Spain
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3
Johan Auwerx, Ecole Polytechnique Federale de Lausanne, SV-IBI1—NCEM1, AI 1151, Station 15, 1015 Lausanne, Switzerland
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4
Rudi Balling, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7, avenue des Hauts-Fourneaux, L-4362 Esch-sur-Alzette, Luxembourg
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5
Sreeparna Banerjee, Department of Biological Sciences, Middle East Technical University, Z-16, 06800 Ankara, Turkey
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6
Anastasios Bezerianos, Biosignal Processing Lab. Department of Medical Physics, ASCLIPIOU 2, School of Medicine, University of Patras, 26500 Patras, Greece
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7
Alessandra Desj Bragonzi, San Raffaele Scientific Institute, via Olgettina 58, 20132 Milano, Italy
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8
Gudrun A Brockmann, Humboldt-Universität, Breeding Biology and Molecular Genetics, Invalidenstraße 42, D-10115 Berlin, Germany
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9
Steve Brown, MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK
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10
Joan Campbell-Tofte, Department of Clinical Biochemistry, Frederiksberg Hospital, DK-2000 Frederiksberg, Denmark
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11
Jan Cendelin, Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, Lidicka 1, 301 66 Plzen, Czech Republic
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12
Aristotelis Chatziioannou, Ethniko Idryma Erevnon National Hellenic Research Foundation, 48 Vassileos Constantinou Ave, 11635 Athens, Greece
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13
Duan Chen, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway
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14
Wim Crusio, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, CNRS UMR 5287, Bat B2—Avenue des Facultés, 33405 Talence, France
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15
Konstantina Dimitrakopoulou, University of Patras, Rio, 26500 Patras, Greece
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16
Juan M Falcon, CIC bioGUNE, Bizkaia Tecnology Park, Building 801-A, 48160 Derio, Spain
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17
Jiri Forejt, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
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18
Paul Franken, University of Lausanne, Center for Integrative Genomics, Genopode building, CH-1015 Lausanne-Dorigny, Switzerland
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19
Leopold F Fröhlich, Medical University of Graz, Institute of Pathology, Auenbruggerplatz 25, A-8036 Graz, Austria
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20
Yann Herault, ICS, TAAM, PHENOMIN, IGBMC, Inserm, CNRS, UdS, GIE-CERBM, 1 Rue Laurent Fries, BP 10142 Parc d'Innovation, 67404 Illkirch, France
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21
Iiris Hovatta, University of Helsinki, Research Program of Molecular Neurology, 00014 Helsingin yliopisto, Finland
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22
Fuad A Iraqi, Sackler Faculty of Medicine, Tel-Aviv University, 69978 Tel-Aviv, Israel
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23
Ritsert C Jansen, University of Groningen, Kerklaan 30, 9751 NN Haren (GN), Netherlands
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24
Leszek Kaczmarek, Polish Academy of Sciences Nencki Institute of Experimental Biology, Pasteura 3, 02-093 Warsaw, Poland
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25
Martien Kas, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Universiteitsweg 100, 3584CG Utrecht, The Netherlands
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26
Ewelina Knapska, Nencki Institute, Pasteur 3, 02-093 Warsaw, Poland
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27
Sulev Koks, Faculty of Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia
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28
Fragiskos Kolisis, NTUA, 9 Iroon Polytechneiou, 15700 Athens, Greece
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29
Michal Korostynski, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland
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30
Frank Lammert, Department of Medicine II, Saarland University Hospital, Saarland University, Kirrberger Street 1, 66421 Homburg, Germany
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31
Hans Lehrach, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
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32
Andreas Lengeling, The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, EH25 9RG Roslin, United Kingdom
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33
Claude Libert, VIB, Rijvisschestraat 120, 9052 Gent, Belgium
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34
Xavier Montagutelli, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris cedex 15, France
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35
Grant Morahan, The Western Australian Institute for Medical Research, University of Western Australia, Perth WA, Australia
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36
Richard Mott, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, OX3 7BN Oxford, United Kingdom
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37
Jean-Jacques Panthier, Institut Pasteur, Mouse functional Genetics Unit, 75015 Paris, France
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38
Ryszard Przewlocki, Institute of Pharmacology, Smetna 12, 31-343 Krakow, Poland
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39
Annamari Ranki, Institute of Clinical Medicine, PL 22 (Meilahdentie 2), University of Helsinki, Helsinki, Finland
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40
Javier Santos, Centro de Biología Molecular Severo Ochoa, Nicolás Cabrera, 1, Campus de la Universidad Autónoma de Madrid, 28049 Madrid, Spain
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41
Feride Severcan, Department of Biological Sciences, Middle East Technical University, Inonu Caddesi, 06531 Ankara, Turkey
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42
Leonard Schalkwyk, King's College London, Institute of Psychiatry PO82, London SE5 8A3, UK
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43
Klaus Schughart, Department of Infection Genetics, Helmholtz Centre for Infection Research, Inhoffenstr 7, D-38124 Braunschweig, Germany
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44
August B Smit, Department of Molecular and Cellular Neurobiology, Research Institute Neurosciences Vrije Universiteit, Faculty of Biology, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
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45
Anton Terasmaa, Department of Physiology, University of Tartu, 50411 Tartu, Estonia
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46
Eero Vasar, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia
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47
Kurt Zatloukal, Medical University of Graz, Institute of Pathology, Auenbruggerplatz 25, A-8036 Graz, Austria
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Schughart, K., Libert, C., SYSGENET consortium. et al. Controlling complexity: the clinical relevance of mouse complex genetics. Eur J Hum Genet 21, 1191–1196 (2013). https://doi.org/10.1038/ejhg.2013.79
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