Table 1 DeepSAGE top 10 upregulated (coefficient +) and downregulated (coefficient −) genes in HD blood samples
Gene | Description | Coefficient a | Expression b | Adjusted P-Value | Protein Function |
|---|---|---|---|---|---|
HYAL2 | Hyaluronoglucosaminidase 2 | +0.4 | 2.6 | 1.0E−03 | Hydrolyzes hyaluronic acid |
LMO2 | LIM domain only 2 | +0.3 | 6.6 | 1.0E−03 | Yolk sac hematopoiesis |
MARC1 | Mitochondrial amidoxime reducing C1 | +0.4 | 5.0 | 5.0E−03 | N-hydroxylate prodrug conversion |
NT5DC2 | 5′-Nucleotidase domain containing 2 | +0.4 | 2.8 | 9.0E−03 | Hydrolase and metal ion binding |
RNF135 | Ring finger protein 135 | +0.3 | 5.8 | 9.0E−03 | DDX58 Ubiquitination~IFN-β |
PROK2 | Prokineticin 2 | +0.5 | 7.9 | 1.0E−02 | Circadian clock—GI contraction |
RPN1 | Ribophorin I | +0.3 | 5.5 | 1.0E−02 | 26S Proteasome ubiquitin binding |
CYSTM1 | Cysteine-rich transmembrane module 1 | +0.4 | 6.0 | 1.0E−02 | Stress tolerance |
VCAN | Versican | +0.3 | 8.2 | 1.6E−02 | Intercellular signaling Binds hyal. acid |
NCF4 | Neutrophil cytosolic factor 4 | +0.3 | 8.9 | 1.8E−02 | NADPH-oxidase component |
ARL4C | ADP-Ribosylation factor-like 4C | −0.3 | 8.2 | 1.0E−03 | Microtubule vesicular transport |
TMEM109 | Transmembrane protein 109 (Mg23) | −0.3 | 7.0 | 6.0E−03 | UVC αB-Crystallin protection |
MACF1 | Microtubule-actin crosslinking factor 1 | −0.2 | 7.2 | 6.0E−03 | Actin-microtubule stabilization |
MDN1 | Midasin homolog | −0.2 | 5.3 | 7.0E−03 | AAA-ATPase(dynein) |
PTPN4 | Protein tyrosine phosphatase NR type 4 | −0.3 | 5.1 | 9.0E−03 | Glutamate receptor signaling |
PRF1 | Perforin 1 | −0.4 | 9.5 | 1.0E−02 | Cytolysis |
CD3G | CD3g Molecule gamma | −0.3 | 7.5 | 1.0E−02 | CD3 complex signal transduction |
NMT2 | N-Myristoyltransferase 2 | −0.3 | 3.4 | 1.0E−02 | N-terminal Myristoylation |
KLRD1 | Killer cell lectin receptor subfamily D 1 | −0.4 | 6.1 | 1.0E−02 | Recognition of MHC class I HLA-E |
GPR56 | G Protein-coupled receptor 56 | −0.4 | 7.3 | 1.0E−02 | Brain cortical patterning |
