Table 2 Fluidigm RT-qPCR technical and biological validation results of DeepSAGE genes
Discovery cohort (n=25) | Independent cohort (n=23) | All samples (n=48) | ||||
|---|---|---|---|---|---|---|
Gene | Description | P-value | Coeff. a | P-value | Coeff. | P-value |
CYSTM1 | Cysteine-rich transmembrane module 1 | 6.0E−03 | 0.5 | 2.0E−03 | 0.5 | 1.0E−04 |
PROK2 | Prokineticin 2 | 1.0E−02 | 1.0 | 2.0E−03 | 0.7 | 1.0E−03 |
AQP9 | Aquaporin 9 | 2.0E−03 | 0.5 | 6.0E−05 | 0.7 | 2.0E−05 |
ZNF238 | Zinc finger protein 238 | 2.0E−02 | 0.3 | 8.0E−03 | 0.5 | 1.0E−03 |
ANXA3 | Annexin 3 | 4.0E−02 | 0.5 | 6.0E−03 | 0.7 | 7.0E−04 |
RNF135 | Ring finger protein 135 | 7.0E−02 | 0.2 | 7.0E−03 | 0.2 | 6.0E−03 |
LMO2 | LIM domain only 2 | 3.0E−02 | 0.2 | 7.0E−02 | 0.2 | 6.0E−03 |
ARL4C | ADP-ribosylation factor like 4 | 3.0E−02 | −0.3 | 9.0E−01 | 0.02 | 7.0E−03 |
TMEM109 | Transmembrane protein 109 | 4.0E−02 | −0.2 | 5.0E−01 | −0.04 | 1.0E−02 |
CEBPA | CCAAT/enhancer binding A | 2.0E−02 | 0.4 | 1.0E−01 | 0.2 | 1.0E−02 |
MACF1 | Microtubule-actin crosslinking F1 | 2.0E−02 | −0.3 | 6.0E−01 | −0.04 | 1.0E−02 |
PTPN4 | Protein tyrosine phosphatase NR 4 | 1.0E−02 | −0.35 | 6.0E−01 | −0.04 | 3.0E−02 |
MARC1 | Mitochondrial amidoxime reducing C1 | 2.0E−02 | 0.5 | 1.0E−01 | 0.4 | 6.0E−02 |
H2AFY | H2A histone family, member Y | 1.0E−01 | 0.15 | 1.0E−01 | 0.15 | 1.0E−01 |
HYAL2 | Hyaluronoglucosaminidase 2 | 1.0E−01 | 0.20 | 4.0E−02 | 0.2 | 1.0E−01 |
NOL3 | Nucleolar protein 3 | 2.0E−01 | 0.15 | 8.0E−02 | 0.2 | 2.0E−01 |
MDN1 | Midasin homolog | 2.0E−01 | −0.15 | 9.0E−01 | NCb | 1.0E−01 |
NT5DC2 | 5′-Nucleotidase domain containing 2 | 5.0E−01 | 0.1 | 2.0E−01 | 0.4 | 3.0E−01 |
RGS14 | Regulator of G-protein signaling 14 | 1.0E−01 | 0.2 | 5.0E−01 | 0.2 | 3.0E−01 |
TAF15 | TATA box—associated factor | 1.0E−01 | −0.1 | 2.0E−01 | 0.15 | 2.0E−01 |
