Figure 1
From: A de novo microdeletion of SEMA5A in a boy with autism spectrum disorder and intellectual disability
Semaphorin phylogeny and structure. (a) Primary structures of the semaphorin family in mammals. (b) Structure of the SEMA5A protein and locations of the coding variants (c.2026C>T, c.2852C>G, c.2866A>G, c.2983C>T). The microdeletion identified in this study is indicated in red and the star represents the de novo missense variant (c.2852C>G) reported by Lossifov et al.35 The conservation of the amino acids is indicated for different species. TM, transmembrane domain; TSP, thrombospondin repeat.
