Figure 2
From: Genomic complexity of urothelial bladder cancer revealed in urinary cfDNA
By examining the BAF plots of the SNP probes for patient 13, the highest aberrant cell load for this patient is observed in cfDNA (greatest separation in bottom plots). The number of TARGET aberrations (3; amplifications of CCND1 (may predict sensitivity to CDK4/6 inhibitors), MDM2 (may predict sensitivity to Nutlins and MDM2 inhibitors) and CDK4 (may predict sensitivity to CDK4/6 inhibitors)) is consistent across all sample types. A degree of tumour heterogeneity is also clear.
